Chemical Probes

We are developing chemical probes at protein level to study the catalytic mechanisms and protein-protein interactions. Here are two published examples:

Hydroxamic acid-Lys analogs bind HDAC1 (histone deacetylase 1)

The figure is modified from eLife 2018, 7:e37231

Propargyl-Lys analogs capture LSD1 (lysine-specific demethylase 1)

The figure is modified from Cell Rep. 2020, 30, 2699

Westlake University, 18 Shilongshan Street, Xihu District, Hangzhou, Zhejiang Province, China 310024

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