A Circular Engineered Sortase for Interrogating Histone H3 in Chromatin

Whedon, S. D.^#; Lee, K.^#; Wang, Z. A.^#; Zahn, E.; Lu, C.; Yapa-Abeywardana, M.; Fairall, L.; Nam, E.; Dubois-Coyne, S.; De Ioannes, P.; Sheng, X.; Andrei, A.; Lundberg, E.; Jiang, J.; Armache, K.; Zhao, Y.; Schwabe, J. W. R.; Wu, M.^*; Garcia, B. A.^*; Cole, P. A.^*

J. Am. Chem. Soc. accepted

Selective Photo Crosslinking to Methylarginine Readers by Sulfonium Probes

Luo, T.; Feng, F.; Zou, K.; Zhao, Y.; Gao, Y.; Wu, M.^*

Bioorg. Med. Chem. accepted.

Development of Site-selective Photo Crosslinking Between Tyrosine and Sulfonium in Methyllysine Readers  

Gao, Y.; Feng, F.; Luo, T.; Han, Y.; Wu, M.^*

Chin. Chem. Lett. accepted.

Scalable Synthesis of Sulfonium and Selenonium Peptides for Selective Methyllysine Reader Crosslinking

Gao, Y.^#; Feng, F.^#; Wu, M.^*

Tetrahedeon Lett. 2024, 151, 155332.

Protocol for Semisynthesis of Histone H4 with Site-specific Modifications Using Irreversible Sortase-mediated Ligation.

Xiao, Y.; Zou, K.; Wu, M.^*

STAR Protoc. accepted.

Robust and Irreversible Sortase-Mediated Ligation by Empolyment of Sarkosyl.

Xiao, Y.; Wu, M.^*

Chem. Eur. J. 2024, e202401961.

A Chemo-selective Enrichment Strategy to Achieve In-depth Coverage of Methyllysine Proteome.

Yan, L.; Zheng, M.; Fan, M.; Yao, R.; Zou, K.; Feng, S.; Wu, M.^* 

Angew. Chem. Int. Ed. 2024, e202408564. 

Single Electron Transfer between Sulfonium and Tryptophan Enables Site-selective Photo Crosslinking of Methyllysine Reader Proteins.

Feng, F.^#; Gao, Y.^#; Zhao, Q.^#; Luo, T.; Yang, Q.; Zhao, N.; Xiao, Y.; Han, Y.; Pan, J.; Feng, S.; Zhang, L.; Wu, M.^*

Nat. Chem. 2024, 16, 1267-1277.

Facile Semisynthesis of Histone H3 Enables Nucleosome Probes for Investigation of Histone H3K79 Modifications.

Zou, K.; Xiao, Y.; Yang, J.; Wu, M.^*

Chin. Chem. Lett. 2024, 35 (10), 109497.

Deciphering Histone H4 Lysine Acetylation and Methylation Via Sortase-Mediated Semisynthesis.

Xiao, Y.; Zou, K.; Yang, J.; Wu, M.^*

Cell Rep. Phys. Sci. 2023, 4 (11), 101638.

Glucose-induced CRL4COP1-p53 Axis Amplifies Glycometabolism to Drive Tumorigenesis.

Su, Y.; Luo, Y.; Zhang, P.; Lin, H.; Pu, W.; Zhang, H.; Wang, H.; Hao, Y.; Xiao, Y.; Zhang, X.; Wei, X.; Nie, S.; Zhang, K.; Fu, Q.; Chen, H.; Huang, N.; Ren, Y.; Wu, M.; Chow, B. K. C.; Chen, X.; Jin, W.; Wang, F.; Zhao, L.; Rao, F.

Mol. Cell 2023, 83 (13), 2316-2331. e7.

Structure of a SIN3–HDAC Complex From Budding Yeast.

Guo, Z.; Chu, C.; Lu, Y.; Zhang, X.; Xiao, Y.; Wu, M.; Gao, S.; Wong, C. C. L.; Zhan, X.; Wang, C. 

Nat. Struct. Mol. Biol. 2023, 30, 753–760.

A General Method to Edit Histone H3 Modifications on Chromatin Via Sortase-Mediated Metathesis.

Yang, Q.; Gao, Y.; Liu, X.; Xiao, Y.; Wu, M.^*

Angew. Chem. Int. Ed. 2022, 61 (52), e202209945.

Histone H2B Deacylation Selectivity: Exploring Chromatin's Dark Matter with an Engineered Sortase.

Wang, Z. A.^#; Whedon, S. D.^#; Wu, M.^#; Wang, S.; Brown, E. A.; Anmangandla, A.; Regan, L.; Lee, K.; Du, J.; Hong, J. Y.; Fairall, L.; Kay, T.; Lin, H.; Zhao, Y.; Schwabe, J. W. R.^*; Cole, P. A.^*

J. Am. Chem. Soc. 2022, 144 (8), 3360-3364.

Lysine-14 Acetylation of Histone H3 in Chromatin Confers Resistance to the Deacetylase and Demethylase Activities of an Epigenetic Silencing Complex.

Wu, M.; Hayward, D.; Kalin, J. H.; Song, Y.; Schwabe, J. W.; Cole, P. A.

eLife 2018, 7, e37231.

Inositol Polyphosphates Intersect with Signaling and Metabolic Networks Via Two Distinct Mechanisms.

Wu, M.; Chong, L. S.; Perlman, D. H.; Resnick, A. C.; Fiedler, D.

Proc. Natl. Acad. Sci. U. S. A. 2016, 113 (44), E6757-E6765.

Elucidating Diphosphoinositol Polyphosphate Function with Nonhydrolyzable Analogues.

Wu, M.; Chong, L. S.; Capolicchio, S.; Jessen, H. J.; Resnick, A. C.; Fiedler, D.

Angew. Chem. Int. Ed. 2014, 53 (28), 7192-7197.

Synthesis and Characterization of Non-hydrolysable Diphosphoinositol Polyphosphate Second Messengers.

Wu, M.; Dul, B. E.; Trevisan, A. J.; Fiedler, D.

Chem. Sci. 2013, 4 (1), 405-410.

2,3,6-Trideoxy Sugar Nucleotides: Synthesis and Stability.

Wu, M.; Meng, Q.; Ge, M.; Bai, L.; Zhou, H.

Tetrahedron Lett. 2011, 52 (44), 5799-5801.