Protocol for Semisynthesis of Histone H4 with Site-specific Modifications Using Irreversible Sortase-mediated Ligation.
Xiao, Y.; Zou, K.; Wu, M.*
STAR Protoc. accepted.
Facile Preparation of Sulfonium Peptide and Protein Probes for Selective Crosslinking of Methyllysine Reader
Zou, K.#; Yang, J.#; Gao, Y.; Feng, F.; Wu, M.*
Chem. Sci. 2025, DOI: 10.1039/D4SC05886K.
Development of Site-selective Photo Crosslinking Between Tyrosine and Sulfonium in Methyllysine Readers
Gao, Y.; Feng, F.; Luo, T.; Han, Y.; Wu, M.*
Chin. Chem. Lett. 2025, 110756.
Selective Photo Crosslinking to Methylarginine Readers by Sulfonium Probes
Luo, T.; Feng, F.; Zou, K.; Zhao, Y.; Gao, Y.; Wu, M.*
Bioorg. Med. Chem. 2025, 118, 11805.
A Circular Engineered Sortase for Interrogating Histone H3 in Chromatin
Whedon, S. D.#; Lee, K.#; Wang, Z. A.#; Zahn, E.; Lu, C.; Yapa-Abeywardana, M.; Fairall, L.; Nam, E.; Dubois-Coyne, S.; De Ioannes, P.; Sheng, X.; Andrei, A.; Lundberg, E.; Jiang, J.; Armache, K.; Zhao, Y.; Schwabe, J. W. R.; Wu, M.*; Garcia, B. A.*; Cole, P. A.*
J. Am. Chem. Soc. 2024, 146, 33914.
Mina53 Demethylates Histone H4 Arginine 3 Asymmetric Dimethylation to Regulate Neural Stem/progenitor Cell Dentity
Zhou, L.#; Zhao, X.#; Sun, J.#; Zou, K.; Huang, X.; Yu, L.; Wu, M.; Wang, Y.; Li, X.*; Yi, W.*
Nat. Commun. 2024, 15, 10227.
Scalable Synthesis of Sulfonium and Selenonium Peptides for Selective Methyllysine Reader Crosslinking
Gao, Y.#; Feng, F.#; Wu, M.*
Tetrahedeon Lett. 2024, 151, 155332.
Robust and Irreversible Sortase-Mediated Ligation by Empolyment of Sarkosyl.
Xiao, Y.; Wu, M.*
Chem. Eur. J. 2024, e202401961.
A Chemo-selective Enrichment Strategy to Achieve In-depth Coverage of Methyllysine Proteome.
Yan, L.; Zheng, M.; Fan, M.; Yao, R.; Zou, K.; Feng, S.; Wu, M.*
Angew. Chem. Int. Ed. 2024, e202408564.
Single Electron Transfer between Sulfonium and Tryptophan Enables Site-selective Photo Crosslinking of Methyllysine Reader Proteins.
Feng, F.#; Gao, Y.#; Zhao, Q.#; Luo, T.; Yang, Q.; Zhao, N.; Xiao, Y.; Han, Y.; Pan, J.; Feng, S.; Zhang, L.; Wu, M.*
Nat. Chem. 2024, 16, 1267-1277.
Facile Semisynthesis of Histone H3 Enables Nucleosome Probes for Investigation of Histone H3K79 Modifications.
Zou, K.; Xiao, Y.; Yang, J.; Wu, M.*
Chin. Chem. Lett. 2024, 35 (10), 109497.
Deciphering Histone H4 Lysine Acetylation and Methylation Via Sortase-Mediated Semisynthesis.
Xiao, Y.; Zou, K.; Yang, J.; Wu, M.*
Cell Rep. Phys. Sci. 2023, 4 (11), 101638.
Glucose-induced CRL4COP1-p53 Axis Amplifies Glycometabolism to Drive Tumorigenesis.
Su, Y.; Luo, Y.; Zhang, P.; Lin, H.; Pu, W.; Zhang, H.; Wang, H.; Hao, Y.; Xiao, Y.; Zhang, X.; Wei, X.; Nie, S.; Zhang, K.; Fu, Q.; Chen, H.; Huang, N.; Ren, Y.; Wu, M.; Chow, B. K. C.; Chen, X.; Jin, W.; Wang, F.; Zhao, L.; Rao, F.
Mol. Cell 2023, 83 (13), 2316-2331. e7.
Structure of a SIN3–HDAC Complex From Budding Yeast.
Guo, Z.; Chu, C.; Lu, Y.; Zhang, X.; Xiao, Y.; Wu, M.; Gao, S.; Wong, C. C. L.; Zhan, X.; Wang, C.
Nat. Struct. Mol. Biol. 2023, 30, 753–760.
A General Method to Edit Histone H3 Modifications on Chromatin Via Sortase-Mediated Metathesis.
Yang, Q.; Gao, Y.; Liu, X.; Xiao, Y.; Wu, M.*
Angew. Chem. Int. Ed. 2022, 61 (52), e202209945.
Histone H2B Deacylation Selectivity: Exploring Chromatin's Dark Matter with an Engineered Sortase.
Wang, Z. A.#; Whedon, S. D.#; Wu, M.#; Wang, S.; Brown, E. A.; Anmangandla, A.; Regan, L.; Lee, K.; Du, J.; Hong, J. Y.; Fairall, L.; Kay, T.; Lin, H.; Zhao, Y.; Schwabe, J. W. R.*; Cole, P. A.*
J. Am. Chem. Soc. 2022, 144 (8), 3360-3364.
Lysine-14 Acetylation of Histone H3 in Chromatin Confers Resistance to the Deacetylase and Demethylase Activities of an Epigenetic Silencing Complex.
Wu, M.; Hayward, D.; Kalin, J. H.; Song, Y.; Schwabe, J. W.; Cole, P. A.
eLife 2018, 7, e37231.
Inositol Polyphosphates Intersect with Signaling and Metabolic Networks Via Two Distinct Mechanisms.
Wu, M.; Chong, L. S.; Perlman, D. H.; Resnick, A. C.; Fiedler, D.
Proc. Natl. Acad. Sci. U. S. A. 2016, 113 (44), E6757-E6765.
Elucidating Diphosphoinositol Polyphosphate Function with Nonhydrolyzable Analogues.
Wu, M.; Chong, L. S.; Capolicchio, S.; Jessen, H. J.; Resnick, A. C.; Fiedler, D.
Angew. Chem. Int. Ed. 2014, 53 (28), 7192-7197.
Synthesis and Characterization of Non-hydrolysable Diphosphoinositol Polyphosphate Second Messengers.
Wu, M.; Dul, B. E.; Trevisan, A. J.; Fiedler, D.
Chem. Sci. 2013, 4 (1), 405-410.
2,3,6-Trideoxy Sugar Nucleotides: Synthesis and Stability.
Wu, M.; Meng, Q.; Ge, M.; Bai, L.; Zhou, H.
Tetrahedron Lett. 2011, 52 (44), 5799-5801.
